Asst. Prof. Sirikachorn Tangkawattana

Sirikachorn Tangkawattana

POSITION TITLE
Assistant Professor of Veterinary Pathobiology; Faculty of Veterinary Medicine, Khon Kaen University

EDUCATION/TRAINING

A. Positions and honors
1993-1999 Lecturer, Department of Veterinary Pathobiology, Khon Kaen University, Khon Kaen, Thailand
1999-present Assistant Professor, Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
1993-present Member of Thai Veterinary Medical Association
1993-present Member of Thai Society of Veterinary Pathology
2000-present Member of Thai Association of Veterinary Laboratory Diagnosticians
2016-present Diplomate, Thai Board of Veterinary Pathology

Honors (selected)
1994-1995 Visiting Scholars in Molecular Pathobiology at the Ohio State University, USA
2004 Excellent poster presentation award in The 2nd Regional APOCP Conference – South East Asia. February
9-11, 2004, Khon Kaen.
2009 Excellent poster presentation award in The 4th Asian Society of Veterinary Pathologists (ASVP)
Conference and Annual Meeting of the Thai Association of Veterinary Laboratory Diagnosticians (TAVLD).
November 19-20, 2009. Chulalongkorn University, Bangkok, Thailand.
2011 Outstanding Vet KKU Alumni in Research (Graduate Study)
2016 Outstanding Vet KKU Alumni in Research, in occasion of the 30th year of establishment of Faculty of
Veterinary Medicine, Khon Kaen University
2017, 2018 Outstanding Vet KKU Alumni in Research 

B. Significant contributions to science:
My works are categorized into 2 main topics:
1. Pathology of liver fluke and CCA: Because of my background is a veterinary pathologist, I have worked on
pathological changes of opisthorchiasis and CCA, particularly in animal model, as well as animal reservoir such as
dogs and cats. A hamster is the model of choice. The pathological findings are similar to those in human. Therefore,
carcinogenesis of O. viverrini-associated CCA could be explained through the hamster model. Furthermore, the
similar changes could be found in animal reservoir. Our study indicated cat is the most important reservoir host. My
selected publications are listed below. I served as either corresponding author or co-author.
2. Liver fluke diseases: This includes the study of 3 liver flukes such as O. viverrini, Opisthorchis felineus (O. felineus)
and Fasciola gigantica (F. gigantica). The studies ranged from laboratory study, epidemiological study to the disease
control model. Our team has expanded what we discover applying to local community, for example, Lawa project or Lawa model which is chosen to be a prototype of opisthorchiasis control in Thailand. The publications are listed
below. I served as either corresponding author or co-author.
Other interests include Pathology and Pathogenesis of Veterinary Oncology.
C. Ongoing Research
 Project Title: “ECOHEALTH EMERGING INFECTIOUS DISEASES RESEARCH IN SOUTH EAST ASIA: Phase II
- Control and Elimination of Helminth Zoonoses in the Greater Mekong Subregion: THAILAND” IDRC with Prof.
Banchob Sripa (PI). Year 2016-2019. Role in this project: co-investigator
 Project Title: Comparative immunopathology of liver fluke infection in susceptible and non-susceptible animal
models. Agency – Thailand National Research Council. Year 2019-2020
Selected Publications
Tangkawattana, P., Tangkawattana, S. and Sangmaneedet, S.1997. Gastrointestinal parasitic infection in swamp buffaloes and attitude of farmers in Mukdaharn province toward parasitic control. KKU Research J. 2(1):26-34.
Rungsipipat, A., Tangkawattana, S., Sailasuta, A., Lohachit, C. and Chariyalertsak, S. 2008. C-erbB-2 oncogene and P21WAF/CIP1 tumor suppressor gene expression as prognostic factors in canine mammary adenocarcinomas. Comp Clin Pathol 17:35-41.
Tangkawattana, S., Kaewkes, S., Pairojkul, C., Tangkawattana, P. and Sripa, B. Mutations of KRAS and TP53 in a Minor Proportion of Opisthorchis viverrini-associated cholangiocarcinoma in a hamster model. Asian Pac J Cancer Prev. 2008 Jan-Mar;9(1):101-6.
Rungsipipat, A. Srichat, W., Charoenvisal, N., Manachai, N., Jearanai, W., Wangnaitham, S., Tangkawattana, P. and Tangkawattana, S. 2008. Clinical evaluation of canine mast cell tumor treatment between combined vinblastine and prednisolone and single prednisolone. Comp Clin Pathol 18:77-84
Young ND, Jex AR, Cantacessi C, Hall RS, Campbell BE, Spithill TW, Tangkawattana S, Tangkawattana P, Laha T, Gasser RB. 2011. A Portrait of the Transcriptome of the Neglected Trematode, Fasciola gigantica-Biological and Biotechnological Implications. PLoS Negl
Trop Dis. 1;5(2):e1004.
L’vova MN, Tangkawattana S, Balthaisong S, Katokhin AV, Mordvinov VA, Sripa B. 2012. Comparative histopathology of Opisthorchis felineus and Opisthorchis viverrini in a hamster model: An implication of high pathogenicity of the European liver fluke. Parasitol Int. 61:167-172.
Aunpromma S, Tangkawattana P, Papirom P, Kanjampa P, Tesana S, Sripa B, Tangkawattana S. 2012. High prevalence of
Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. Parasitol Int. 61: 60-64.
Sripa B, Tangkawattana S, Laha T, Kaewkes S, Mallory FF, Smith JF, Wilcox BA. 2015. Toward integrated opisthorchiasis control in northeast Thailand: the Lawa project. Acta Trop. 141(Pt B):361-7.
Rungsipipat A, Sitthicharoenchai P, Marlow P, Prutthithaworn P, Tangkawattana S. 2016. Expression of metallothionein protein relating to proliferative cell index in malignant feline mammary tumors using high throughput tissue microarray technique. Comp Clin Pathol. 25(2): 449-57. (online since 27 Nov 2015).
Teimoori S, Arimatsu Y, Laha T, Kaewkes S, Sereerak P, Tangkawattana S, Brindley PJ, Sripa B. 2015. Immunodiagnosis of
opisthorchiasis using parasite cathepsin F. Parasitol Res. 114(12):4571-8
Hanpanich P, Laha T, Sripa B, Mairiang E, Sereerak P, Upontain S, Tangkawattana P, Brindley PJ, Tangkawattana S. Decreased risk of Cholangiocarcinogenesis following repeated cycles of Opisthorchis viverrini Infection-Praziquantel treatment: Magnetic resonance imaging (MRI) and histopathological study in a hamster model. Parasitol Int. 2017;66:464-470.
Setthawongsin C, Techangamsuwan S, Tangkawattana S, Rungsipipat A. 2016. Cell-based polymerase chain reaction for canine transmissible venereal tumor (CTVT) diagnosis. J Vet Med Sci. Aug 1;78(7):1167-73. doi: 10.1292/jvms.15-0710.
Sirivisoot S, Techangamsuwan S, Tangkawattana S, Rungsipipat A. 2016. Application of Immunophenotyping and Heteroduplex Polymerase Chain Reaction (hPARR) for Diagnosis of Canine Lymphomas. Asian Pac J Cancer Prev. 2016;17(6):2909-16.
Teimoori S, Arimatsu Y, Laha T, Kaewkes S, Sereerak P, Sripa M, Tangkawattana S, Brindley PJ, Sripa B. 2016. Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. Parasitol Int. Apr 29. pii: S1383-5769(16)30093-9. doi: 10.1016/j.parint.2015.10.011. [Epub ahead of print]
PMID: 27140305
Sereerak P, Upontain S, Tangkawattana P, Mallory FF, Sripa B, Tangkawattana S. Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis.
Parasitol Int. 2017;66:448-452.

Sripa B, Tangkawattana S, Sangnikul T. The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. Parasitol Int. 2017 Aug;66(4):346-354.
Suwannatrai K, Suwannatrai A, Tabsripair P, Welbat JU, Tangkawattana S, Cantacessi C, Mulvenna J, Tesana S, Loukas A, Sotillo J. Differential Protein Expression in the Hemolymph of Bithynia siamensis goniomphalos Infected with Opisthorchis viverrini. PLoS Negl Trop Dis. 2016 Nov 28;10(11):e0005104. doi: 10.1371/journal.pntd.0005104.
Aunpromma S,, Kanjampa P, Papirom P, Tangkawattana S, Tangkawattana P, Tesana S, Boonmars T, Suwannatrai A, Uopsai S,
Sukon P, Sripa B. Prevalence and risk factors for Opisthorchis viverrini infection among cats and dogs in six districts surrounding the
Ubonratana Dam, an endemic area for human opisthorchiasis in Northeastern Thailand. Southeast Asian J Trop Med Public Health. 2016. 47(6):1153-1159.
Vinh HQ, Phimpraphai W, Tangkawattana S, Smith JF, Kaewkes S, Dung DT, Duong TT, Sripa B. Risk factors for Clonorchis sinensis infection transmission in humans in northern Vietnam: A descriptive and social network analysis study. Parasitol Int. 2017 Apr;66(2):74-82.
Phimpraphai W, Tangkawattana S, Sereerak P, Kasemsuwan S, Sripa B. Social network analysis of food sharing among households in opisthorchiasis endemic villages of Lawa Lake, Thailand. Acta Trop. 2017 Feb 8;169:150-156.
S. Sirivisoot, S. Techangamsuwan, S. Tangkawattana, A. Rungsipipat. Pax5 as a potential candidate marker for canine B-cell
lymphoma. Veterinarni Medicina, 62, 2017 (02): 74–80.
Sirivisoot S, Teewasutrakul P, Techangamsuwan S, Tangkawattana S, Rungsipipat A. Monitoring minimal residual disease in canine lymphomas treated with modified L-COP or L-CHOP protocols. Acta Vet Hung. 2018 Mar;66(1):66-84.
Saijuntha W, Duenngai K, Tangkawattana S, Petney TN, Andrews RH, Sithithaworn P. Recent Advances in the Diagnosis and Detection of Opisthorchis viverrini Sensu Lato in Human and Intermediate Hosts for Use in Control and Elimination Programs. Adv Parasitol. 2018;101:177-214.
Tangkawattana S, Tangkawattana P. Reservoir Animals and Their Roles in Transmission of Opisthorchis viverrini. Adv Parasitol. 2018;101:69-95.
Phimpraphai W, Tangkawattana S, Kasemsuwan S, Sripa B. Social Influence in Liver Fluke Transmission: Application of Social Network Analysis of Food Sharing in Thai Isaan Culture. Adv Parasitol. 2018;101:97-124.
Setthawongsin C, Tangkawattana S, Rungsipipat A, Techangamsuwan S. Computerized Cytomorphometric and Cytomorphological Analysis of Canine Transmissible Venereal Tumours. J Comp Pathol. 2018 Aug;163:18-22.
Upontain S, Sereerak P, Laha T, Sripa B, Tangkawatana S, Brindley PJ, Tangkawattana S. Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis. APJCP 2018 Sep; 19(9): 2437-2445.
Tangkawattana S, Sripa B. Integrative EcoHealth/One Health Approach for Sustainable Liver Fluke Control: The Lawa Model. Adv Parasitol. 2018;102:115-139.
Sripa B, Jumnainsong A, Tangkawattana S, Haswell MR. Immune Response to Opisthorchis viverrini Infection and Its Role in Pathology. Adv Parasitol. 2018;102:73-95
Sripa B, Tangkawattana S, Brindley PJ. Update on Pathogenesis of Opisthorchiasis and Cholangiocarcinoma. Adv Parasitol.
2018;102:97-113.
Salao K, Watakulsin K, Mairiang E, Suttiprapa S, Tangkawattana S, Edwards SW, Sripa B. High macrophage activities are associated with advanced periductal fibrosis in chronic Opisthorchis viverrini infection. Parasite Immunol. 2018 Nov 18:e12603. doi: 10.1111/pim.12603. [Epub ahead of print]